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Furthermore, the threshold effect is consistent with the concept that methionine synthase activity may become saturated beyond a certain B12 concentration [17], explaining the diminishing returns observed at higher levels

10.1038/s41598-020-57758-5 63 GuoJ

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For instance, CpG island hypermethylation-mediated silencing of miR-124a has been observed in various lung cancer cell lines, including H358, CALU3, A549, A427, H2126, and H209 [83]